Calcium-D-Glucarate & DIM
Has anyone ever used Calcium-D-Glucarate in association with DIM (Diindolylmethane) therapy for endometriosis?
From what I have read, DIM together with Calcium d-glucarate helps to balance the sex hormones - estrogen. It appears that when estrogen is broken down in your body, it can either form beneficial or harmful estrogenic metabolites, and DIM helps your body break down estrogen into beneficial metabolites.
Studies have shown that endometriosis tissues have different supplies of estrogen, its own supply due to the intrinsic aromatase (Bulun SE, Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. PubMed 2005) activity, the ovaries and the peripheral fat (Bulun SE, Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. PubMed 2005).
Related articles:
https://www.rupahealth.com/post/calcium-d-glucarates-effectiveness-in-estrogen-balance-an-integrative-endocrine-view
https://pubmed.ncbi.nlm.nih.gov/12197785/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3048776/#:~:text=These%20results%20suggest%20that%20DIM,5%E2%80%939%2C26).
Hi
. I see you are new here. Welcome to the community! Have you been diagnosed long? I don't see any mention of calcium-D-glucarate in our archives, but, hopefully, others will chime in here if they have tried it. Have you asked your doctor whether calcium-D-glucarate might be beneficial for you? Wishing you the best. - Lori (Team Member) I'm new to the forum, really. My daughter was diagnosed with endometriosis in 2021 and in 2022 she had her first surgery. I registered on the forum with the intention of keeping up to date with the latest types of therapy available for this disease. I have not yet asked our doctor about therapy based on Calcium d-glucarate - I wanted to see if there are other types of treatment at the international level compared to the classic ones, which unfortunately do not give the expected results. In the last few weeks I searched the internet for information about this disease which, by the way, affects at least 10% of women globally according to some statistics, and according to other statistics, which also include asymptomatic or very mild cases. symptoms , 30% and I can't believe how little progress has been made in identifying the causes of this disease and its treatment . It is a disease that really only affects women (or mostly women because there are also rare cases of men affected by this disease) but each of us has a mother after all ...
Hi
. What a coincidence. My daughter was also diagnosed in 2020 and had surgery the same year as your daughter. The lack of attention and resources given this disease really is maddening. It's a helpless feeling to see someone you love endure all that goes with it, especially at a young age. My daughter still has some symptoms after surgery even with hormone treatment, but she recently found a wonderful new doctor who encouraged her to work on reducing inflammation through diet and lifestyle. That has helped. She is always so positive though. Her posivity helps me as well. How is your daughter doing? Please know we are here for you and your daughter. Warmly, Lori (Team Member)
I'm glad to hear that you found a doctor who can guide you towards a diet and lifestyle that will reduce your symptoms. We tried a homeopathic treatment but it did not give results and now we have cysts on the ovaries again and we are going to have a new surgical intervention.
Initially, we found out that we have endometriosis when we were looking for treatment for acne - in fact, the acne was caused by endometriosis.
My daughter is also a positive person, but I know that in her soul she is worried. We will also focus on diet-based therapy, even though my daughter is now eating healthy.I am sure that there are resources in and around the community of endometriosis patients who can get involved in a project that could take a small step towards finding a better treatment for those affected by this disease. What differentiates us from companies/universities/medical organizations is the motivation - we are directly affected by this disease.
My son was diagnosed with type 1 diabetes at the age of 6, and while looking for various solutions to monitor blood sugar, I discovered on the Internet a community project (open source) called "We are not waiting" that developed blood sugar monitoring systems ( SW) and documentation for building the related HW component. That was in 2012 and more recently there is documentation for the artificial pancreas within the same project - the insulin pump that injects insulin in close correlation with the blood sugar measured automatically by a sensor every 5 min. So it is possible!I know it's not easy, but somehow we have to try to do something to boost things for this disease as well. I think we need to take over the phrase "WeAreNotWaiting" - we need a #WeAreNotWaitingToo. Let's start, for example, to form a work team in which to analyze in which directions we could boost/support research for this disease. For example, we could carry out some studies in which we analyze data related to the age at which the first symptoms appeared, where the condition was located, stress factors, the country/region where the subject lives, eating habits before diagnosis, ... data that we then try to correlate to see what we get.
There is no perfect disease - for every disease there is a silver bullet!In the meantime, I found an interesting article that shows possible causes of this disease:
https://endometriosis.org/endometriosis/causes/Thanks for sharing the article link. It's very interesting. I will share it with my daughter. The dietary changes simply help with inflammation, which aggrevates both her endometriosis and her joint disorder. I assume she will also need surgery again someday, but she finally feels like she has a doctor who listens. That's not easy to find with this disease.
How awesome it would be if your son could someday get the artificial pancreas. That could be lifechanging. It sounds like you have really had to hone your advocacy skills as a parent. If you are interested, we a sister community for advocates, SocialHealthNetwork.com. It's a very active and supportive community with lots of great resources. - Lori (Team Member)
