Danocrine (danazol)

Reviewed by: HU Medical Review Board | Last reviewed: February 2022 | Last updated: October 2022

Danocrine (danazol) is approved for people with endometriosis to treat endometriosis-related pain. Danazol is a synthetic steroid that suppresses ovarian function. It affects the levels of certain hormones in the body that are related to the menstrual cycle and other aspects of the reproductive system.1-3

What are the ingredients in Danocrine?

The active ingredient in Danocrine is danazol. It is a synthetic steroid that impacts hormone levels in the body.1

How does Danocrine work?

Danocrine interacts with complex hormonal pathways in the body. Danocrine suppresses ovarian function and the pituitary-ovarian axis. This decreases the amount of estrogen in the body. This decrease can shrink endometriosis lesions. It may also prevent them from thickening and breaking down, decreasing endometriosis-related pain. Danocrine also acts on androgen receptors, increasing male hormone levels in the body.1-3

Possible side effects

The most common side effects of Danocrine include:1

  • Weight gain
  • Sweating or oily skin
  • Acne
  • Hair loss
  • Deepening of the voice
  • Swelling
  • Abnormal hair growth, such as on the face in women
  • Abnormal menstrual bleeding or spotting
  • Absence of period (amenorrhea)
  • Hot flashes
  • Vaginal dryness
  • Vaginal irritation
  • Reduction in breast size
  • Emotional instability and mental health issues like anxiety or depression

These are not all the possible side effects of Danocrine. Talk to your doctor about what to expect or if you experience any changes that concern you during treatment with Danocrine.

Things to know about Danocrine

Danocrine increases the risk of serious health complications, including:1-3

  • Blood clots
  • Heart issues like stroke
  • Increased fluid and pressure in the skull (intracranial hypertension)
  • Liver problems

Danocrine can harm an unborn baby. People who can become pregnant should use birth control during treatment and for some time after the last dose of Danocrine. While Danocrine may impact the menstrual cycle, including causing an absence of a person's period, it is not considered an effective contraceptive. Talk to your doctor about your options for birth control while taking Danocrine. 1

Before beginning treatment with Danocrine, tell your doctor if you:1

  • Have a history of mental illness
  • Have a history of hormone-related conditions
  • Have a history of hormone-sensitive cancer such as breast cancer
  • Have a history of epilepsy or seizures
  • Have a history of migraine
  • Have any heart conditions
  • Have any issues with your liver or kidneys
  • Have diabetes or are pre-diabetic

Before beginning treatment for endometriosis, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

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